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SCC4 Rabbit pAb (bs-17275R)  
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50ul/1180.00元
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200ul/2800.00元
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產品編號 bs-17275R
英文名稱 SCC4 Rabbit pAb
中文名稱 同類型染色單體凝聚蛋白4抗體
別    名 K0892; KIAA0892; Mau 2; Mau 2L; mau-2; Mau2; SCC4_HUMAN; MAU2L; Scc 4; sister chromatid cohesion 4.  
研究領域 細胞生物  免疫學  染色質和核信號  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 69 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCC4: 51-150/613 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.

Function:
Scc4 (Mau2) is the metazoan homologue of Scc4 in S. cerevisiae. In yeast, Scc4 binds to Scc2 to form an essential complex that loads cohesion onto chromosomes. Similarly, the Scc4 / Mau2 protein in metazoans plays a significant role in sister chromatid separation and in loading of cohesin onto chromatin. The Scc2-Scc4 complex is tethered to pre-replication complexes through the Cdc7-Drf1 protein kinase DDK.

Subunit:
Interacts (via N-terminus) with NIPBL to form the cohesion loading complex.

Subcellular Location:
Nucleus, nucleoplasm. Note=Binds to chromatin from the end of mitosis until prophase.

Similarity:
Belongs to the SCC4/mau-2 family.
Contains 4 TPR repeats.

SWISS:
Q9Y6X3

Gene ID:
23383

Database links:

Entrez Gene: 23383 Human

Entrez Gene: 74549 Mouse

Omim: 614560 Human

SwissProt: Q9Y6X3 Human

SwissProt: Q9D2X5 Mouse

SwissProt: B4ZIX8 Xenopus laevis

Unigene: 654939 Human

Unigene: 269061 Mouse



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