| 產(chǎn)品編號 | bs-5765R |
| 英文名稱 | LANCL2 Rabbit pAb |
| 中文名稱 | G蛋白偶聯(lián)受體69B |
| 別 名 | G protein coupled receptor 69B; LanC(bacterial lantibiotic synthetase component C) like 2; TASP; Testis specific adriamycin sensitivity protein; LANC2_HUMAN. |
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Specific References (1) | bs-5765R has been referenced in 1 publications.
[IF=3.37] Dylan Maixner. et al. Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord :. MOL PAIN. 0;(): WB ; Rat.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 染色質(zhì)和核信號 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 51 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LANCL2: 331-430/460 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
LANCL2 belongs to the LanC like protein family. It is expressed in the brain and testis. LANCL2 is a bystander gene coamplified and overexpressed with epidermal growth factor receptor (EGFR) in 20% of all glioblastomas. Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin). Function: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Subunit: Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association. Subcellular Location: Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin). Tissue Specificity: Expressed in brain and testis. Post-translational modifications: Myristoylated. Essential for membrane association. Similarity: Belongs to the LanC-like protein family. SWISS: Q9NS86 Gene ID: 55915 Database links: Entrez Gene: 55915 Human SwissProt: Q9NS86 Human Unigene: 595384 Human |
